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dc.contributor.authorMilanés-Guisado, Yusnelkises_ES
dc.contributor.authorGutiérrez Valencia, Aliciaes_ES
dc.contributor.authorTrujillo-Rodríguez, María-
dc.contributor.authorEspinosa, Nuria-
dc.contributor.authorViciana, Pompeyo-
dc.contributor.authorLópez-Cortés, Luis F.-
dc.date.accessioned2019-03-25T12:50:02Z-
dc.date.available2019-03-25T12:50:02Z-
dc.date.issued2018-10-22-
dc.identifier.citationPLoS ONE 13(10): e0205777 (2018)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/178479-
dc.description.abstract[Objectives] To analyse the correlation and concordance between aCD4, CD4%, CD4/CD8, their intra-patient variability, and to compare the immune recovery (IR) rates based on the three parameters in HIV-infected patients after starting antiretroviral therapy.es_ES
dc.description.abstract[Methods] From a prospectively followed cohort, patients who maintained HIV-RNA suppression in ≥95% of the determinations throughout the follow-up were selected. IR was defined as aCD4 >650/μl, CD4% ≥38% or CD4/CD8 ≥1.-
dc.description.abstract[Results] A total of 1164 patients with a median follow-up of 5 years were analysed. The increases in aCD4, CD4% and CD4/CD8 were highest during the first year and considerably lower thereafter regardless of baseline aCD4. The annual increases in aCD4 showed poor correlations with those of CD4% (r = 0.143–0.250) and CD4/CD8 (r = 0.101–0.192) but were high between CD4% and CD4/CD8 (r = 0.765–0.844; p<0.001). The median intra-annual coefficients of variation for aCD4, CD4/CD8 and CD4% were 12.5, 8.5 and 6.6, respectively. After five years, 66.7%, 41.6% and 42.1% of the patients reached aCD4 >650/μl, CD4% ≥38%, and CD4/CD8 ≥1, respectively, while only 31% achieved both aCD4 and CD4/CD8 target values.-
dc.description.abstract[Conclusions] The increases in aCD4 poorly correlate with those of CD4% and CD4/CD8. IR rates based on aCD4 significantly overstate those obtained by CD4% and CD4/CD8. CD4% and CD4/CD8 are more stable markers than aCD4 and should be taken into account to monitor the IR after treatment initiation.-
dc.description.sponsorshipThis work was supported by Red de Investigación en SIDA RD16/0025/0020-ISCIII-FEDER.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleAbsolute CD4+ T cell count overstate immune recovery assessed by CD4+/CD8+ ratio in HIV-infected patients on treatmentes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0205777-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0205777es_ES
dc.identifier.e-issn1932-6203-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderRed Española de Investigación en SIDA-
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.contributor.orcidLópez-Cortés, Luis F. [0000-0002-3804-3458]es_ES
dc.identifier.pmid30346965-
item.fulltextWith Fulltext-
item.openairetypeartículo-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
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