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http://hdl.handle.net/10261/178141
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dc.contributor.author | Lancelot, Alexandre | - |
dc.contributor.author | González-Pastor, Rebeca | - |
dc.contributor.author | Claveria-Gimeno, Rafael | - |
dc.contributor.author | Romero, Pilar | - |
dc.contributor.author | Abian, Olga | - |
dc.contributor.author | Martín-Duque, Pilar | - |
dc.contributor.author | Serrano, José Luis | - |
dc.contributor.author | Sierra, Teresa | - |
dc.date.accessioned | 2019-03-19T14:22:18Z | - |
dc.date.available | 2019-03-19T14:22:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1039/c8tb00639c | - |
dc.identifier | issn: 2050-750X | - |
dc.identifier.citation | Journal of Materials Chemistry B 6(23): 3956-3968 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/178141 | - |
dc.description.abstract | Novel cationic poly(ester amide) dendrimers have been synthesized by copper(i) azide-alkyne cycloaddition (CuAAC) of a tripropargylamine core and azide-terminated dendrons, in turn prepared by iterative amide coupling of the new monomer 2,2′-bis(glycyloxymethyl)propionic acid (bis-GMPA). The alternation of ester and amide groups provided a dendritic scaffold that was totally biocompatible and degradable in aqueous media at physiological and acidic pH. The tripodal dendrimers naturally formed rounded aggregates with a drug that exhibited low water solubility, camptothecin, thus improving its cell viability and anti-Hepatitis C virus (anti-HCV) activity. The presence of numerous peripheral cationic groups enabled these dendrimers to form dendriplexes with both pDNA and siRNA and they showed effective in vitro siRNA transfection in tumoral and non-tumoral cell lines. | - |
dc.description.sponsorship | This work was financially supported by the MINECO-FEDER funds (under the projects CTQ2015-70174-P and MAT2015-66208-C3-1-P), the Miguel Servet Program from the Instituto de la Salud Carlos III (CPII13/00017 to O.A.), Instituto de Salud Carlos III and European Union (ERDF/ESF, ‘‘Investing in your future’’) (PI15/00663) and the Gobierno de Aragón-FSE (E04 and B01 research groups). Centro de Investigacion Biomédica en Red en Enfermedades Hepaticas y Digestivas (CIBERehd); and Asociación Española de Gastroenterologia (AEG). A. L. and R. C.-G. thank the MECD for their FPU grants (FPU12/05210 and FPU13/3870). R. G.-P. and R. C.-G. thank the DGA for their EPIF grants. | - |
dc.publisher | Royal Society of Chemistry (UK) | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70174-P | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-66208-C3-1-P | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | - |
dc.title | Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1039/c8tb00639c | - |
dc.relation.publisherversion | https://doi.org/10.1039/c8tb00639c | - |
dc.date.updated | 2019-03-19T14:22:18Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Gobierno de Aragón | - |
dc.contributor.funder | Diputación General de Aragón | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010067 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (ICMA) Artículos (IQF) Artículos |
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cationicdend.pdf | 1,15 MB | Adobe PDF | Visualizar/Abrir |
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