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Cationic poly(ester amide) dendrimers: alluring materials for biomedical applications

AuthorsLancelot, Alexandre; González-Pastor, Rebeca; Claveria-Gimeno, Rafael; Romero, Pilar ; Abian, Olga ; Martín-Duque, Pilar; Serrano, José Luis; Sierra, Teresa
Issue Date2018
PublisherRoyal Society of Chemistry (UK)
CitationJournal of Materials Chemistry B 6(23): 3956-3968 (2018)
AbstractNovel cationic poly(ester amide) dendrimers have been synthesized by copper(i) azide-alkyne cycloaddition (CuAAC) of a tripropargylamine core and azide-terminated dendrons, in turn prepared by iterative amide coupling of the new monomer 2,2′-bis(glycyloxymethyl)propionic acid (bis-GMPA). The alternation of ester and amide groups provided a dendritic scaffold that was totally biocompatible and degradable in aqueous media at physiological and acidic pH. The tripodal dendrimers naturally formed rounded aggregates with a drug that exhibited low water solubility, camptothecin, thus improving its cell viability and anti-Hepatitis C virus (anti-HCV) activity. The presence of numerous peripheral cationic groups enabled these dendrimers to form dendriplexes with both pDNA and siRNA and they showed effective in vitro siRNA transfection in tumoral and non-tumoral cell lines.
Publisher version (URL)https://doi.org/10.1039/c8tb00639c
Identifiersdoi: 10.1039/c8tb00639c
issn: 2050-750X
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