Antimicrobial, Antibiofilm and Cytotoxicity Activity of a New Acridine Hyperbranched Polymer in Solution and on Cotton Fabric

Abstract

For the first time a fluorescent hyperbranched polymer modified with acridine (P1000-Acrid) was tested in vitro for antimicrobial activity against different model pathogens. The results showed strong activity of the compound against the used Gram-positive and Gram negative bacteria and yeasts. Cytotoxicity effect of P1000-Acrid has been studied towards HEp-2 cell line. The antibacterial finishing of cotton fabric treated with the P1000-Acrid was evaluated towards Grampositive and Gram-negative bacteria. It has been shown that the studied P1000-Acrid polymer reduces bacterial growth and prevents the formation of biofilm. The obtained results indicate that the studied P1000-Acrid hyperbranched polymer possess good antimicrobial potential with the greatest effectiveness against the used Gram-positive strains.