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| Título: | Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases |
Autor: | González-Roura, Albert; Navarro, Isabel; Delgado Cirilo, Antonio CSIC ORCID; Llebaria, Amadeu CSIC ORCID; Casas, Josefina CSIC ORCID | Palabras clave: | Hydrolases Inhibitors Metalloenzymes Protein structures Zinc |
Fecha de publicación: | 2-feb-2004 | Editor: | Gesellschaft Deutscher Chemiker John Wiley & Sons |
Citación: | Angewandte Chemie International Edition 43(7): 862-865 (2004) | Resumen: | Shaping up for inhibition: Identification of three-dimensional structural similarities (see picture) between the active sites of zinc dinuclear aminopeptidases and trinuclear phospholipase C hydrolytic enzymes that are not related by sequence or tertiary structure led to the discovery of phospholipase C inhibition by α-aminohydroxamic acids, a typical family of aminopeptidase inhibitors. | Descripción: | 4 pages, 3 figures, 1 table.-- PMID: 14767959 [PubMed].-- Printed version published Feb 6, 2004. | Versión del editor: | http://dx.doi.org/10.1002/anie.200352241 | URI: | http://hdl.handle.net/10261/17770 | DOI: | 10.1002/anie.200352241 | ISSN: | 1433-7851 | E-ISSN: | 1521-3773 |
| Aparece en las colecciones: | (IQAC) Artículos |
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