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Title

Disclosing new inhibitors by finding similarities in three-dimensional active-site architectures of polynuclear zinc phospholipases and aminopeptidases

AuthorsGonzález-Roura, Albert; Navarro, Isabel; Delgado Cirilo, Antonio ; Llebaria, Amadeu ; Casas, Josefina
KeywordsHydrolases
Inhibitors
Metalloenzymes
Protein structures
Zinc
Issue Date2-Feb-2004
PublisherGesellschaft Deutscher Chemiker
John Wiley & Sons
CitationAngewandte Chemie International Edition 43(7): 862-865 (2004)
AbstractShaping up for inhibition: Identification of three-dimensional structural similarities (see picture) between the active sites of zinc dinuclear aminopeptidases and trinuclear phospholipase C hydrolytic enzymes that are not related by sequence or tertiary structure led to the discovery of phospholipase C inhibition by α-aminohydroxamic acids, a typical family of aminopeptidase inhibitors.
Description4 pages, 3 figures, 1 table.-- PMID: 14767959 [PubMed].-- Printed version published Feb 6, 2004.
Publisher version (URL)http://dx.doi.org/10.1002/anie.200352241
URIhttp://hdl.handle.net/10261/17770
DOI10.1002/anie.200352241
ISSN1433-7851
E-ISSN1521-3773
Appears in Collections:(IQAC) Artículos
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