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dc.contributor.author | Gumí Audenis, Berta | es_ES |
dc.contributor.author | Illa Tuset, Silvia | es_ES |
dc.contributor.author | Grimaldi, Natascia | es_ES |
dc.contributor.author | Pasquina Lemonche, Laia | es_ES |
dc.contributor.author | Ferrer Tasies, Lidia P. | es_ES |
dc.contributor.author | Sanz, Fausto | es_ES |
dc.contributor.author | Veciana, Jaume | es_ES |
dc.contributor.author | Ratera, Immaculada | es_ES |
dc.contributor.author | Faraudo, Jordi | es_ES |
dc.contributor.author | Ventosa, Nora | es_ES |
dc.contributor.author | Giannotti, Marina I. | es_ES |
dc.date.accessioned | 2019-03-08T11:37:24Z | - |
dc.date.available | 2019-03-08T11:37:24Z | - |
dc.date.issued | 2018-12-28 | - |
dc.identifier.citation | Nanoscale 10(48): 23001-23011 (2018) | es_ES |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | http://hdl.handle.net/10261/177551 | - |
dc.description.abstract | Quatsomes (QS) are unilamellar nanovesicles constituted by quaternary ammonium surfactants and sterols in defined molar ratios. Unlike conventional liposomes, QS are stable upon long storage such as for several years, they show outstanding vesicle-to-vesicle homogeneity regarding size and lamellarity, and they have the structural and physicochemical requirements to be a potential platform for site-specific delivery of hydrophilic and lipophilic molecules. Knowing in detail the structure and mechanical properties of the QS membrane is of great importance for the design of deformable and flexible nanovesicle alternatives, highly pursued in nanomedicine applications such as the transdermal administration route. In this work, we report the first study on the detailed structure of the cholesterol : CTAB QS membrane at the nanoscale, using atomic force microscopy (AFM) and spectroscopy (AFM-FS) in a controlled liquid environment (ionic medium and temperature) to assess the topography of supported QS membranes (SQMs) and to evaluate the local membrane mechanics. We further perform molecular dynamics (MD) simulations to provide an atomistic interpretation of the obtained results. Our results are direct evidence of the bilayer nature of the QS membrane, with characteristics of a fluid-like membrane, compact and homogeneous in composition, and with structural and mechanical properties that depend on the surrounding environment. We show how ions alter the lateral packing, modifying the membrane mechanics. We observe that according to the ionic environment and temperature, different domains may coexist in the QS membranes, ascribed to variations in molecular tilt angles. Our results indicate that QS membrane properties may be easily tuned by altering the lateral interactions with either different environmental ions or counterions. | es_ES |
dc.description.sponsorship | We acknowledge financial support from the Generalitat de Catalunya (AGAUR, 2017 SGR 918 and 2017 SGR 1442), the Spanish Ministry of Economy and Competitiveness (MINECO), through the “Severo Ochoa” Programme for Centres of Excellence in R&D with Grant SEV-2015-0496, the MINECO and FEDER for the CTQ2015-66194-R and MAT2016-80826-R projects, the Instituto de Salud Carlos III, through “Acciones CIBER” and CIBER-BBN Biofilm-Attack and FlexQS-skin projects, and the European Cooperation in Science and Technology through the COST Action CA15126. We thank CESGA Supercomputing Center for technical support and the use of computational resources. The computer simulations reported in this work have been developed under the Material Science PhD program in the Barcelona Autonomous University (UAB). The reported synthesis and characterization of QS has been performed by the ICTS “NANBIOSIS”, more specifically by the Biomaterial Processing and Nanostructuring Unit (U6), Unit of the CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) located at the Institute of Materials Science of Barcelona (ICMAB-CSIC). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0496 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-66194-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2016-80826-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Quatsome | es_ES |
dc.subject | Membrane | es_ES |
dc.subject | AFM | es_ES |
dc.subject | Force spectroscopy | es_ES |
dc.subject | Nanomechanics | es_ES |
dc.subject | Molecular dynamics | es_ES |
dc.subject | Atomistic simulations | es_ES |
dc.subject | Bilayer structure | es_ES |
dc.subject | Nanovesicles | es_ES |
dc.title | Insights into the structure and nanomechanics of a quatsome membrane by force spectroscopy measurements and molecular simulations | es_ES |
dc.type | artículo | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/C8NR07110A | es_ES |
dc.embargo.terms | 2019-12-28 | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (España) | es_ES |
dc.contributor.funder | European Cooperation in Science and Technology | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100005053 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000921 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
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