Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/177392
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dc.contributor.authorZaouali, Mohamed A.es_ES
dc.contributor.authorPanisello-Roselló, Arnaues_ES
dc.contributor.authorLópez, Alexandrees_ES
dc.contributor.authorFolch-Puy, Emmaes_ES
dc.contributor.authorCastro-Benítez, Carloses_ES
dc.contributor.authorAdam, Renées_ES
dc.contributor.authorRoselló-Catafau, Joanes_ES
dc.date.accessioned2019-03-06T13:18:16Z-
dc.date.available2019-03-06T13:18:16Z-
dc.date.issued2017-05-
dc.identifier.citationTransplantation Proceedings 49(4): 765-769 (2017)es_ES
dc.identifier.issn0041-1345-
dc.identifier.urihttp://hdl.handle.net/10261/177392-
dc.description.abstract[Background] Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide +–dependent histone deacetylase that regulates various pathways involved in ischemia-reperfusion injury (IRI). Moreover, high-mobility group box 1 protein (HMGB1) has also been involved in inflammatory processes during IRI. However, the roles of both SIRT1 and HMGB1 in liver preservation is poorly understood. In this communication, we evaluated the potential relationship between SIRT1 and HMGB1 in steatotic and non-steatotic liver grafts preserved in Institute Georges Lopez solution (IGL-1) preservation solution enriched or not enriched with trimetazidine (TMZ).es_ES
dc.description.abstract[Methods] Steatotic and non-steatotic livers were preserved in IGL-1 preservation solution (24 hours, 4°C), enriched or not enriched with TMZ (10 μmol/L), and then submitted to ex vivo reperfusion (2 hours; 37°C). Liver injury (AST/ALT) and function (bile output, vascular resistance) were evaluated. SIRT1, HMGB1, autophagy parameters (beclin-1, LC3B), PPAR-γ, and heat-shock protein (HO-1, HSP70) expression were determined by means of Western blot. Also, we assessed oxidative stress, mitochondrial damage (glutamate dehydrogenase), and TNF-α levels.es_ES
dc.description.abstract[Results] Elevated SIRT1 and enhanced autophagy were found after reperfusion in steatotic livers preserved in IGL-1+TMZ when compared with IGL-1. However, these changes were not seen in the case of non-steatotic livers. Also, HO-1 increases in the IGL-1 + TMZ group were evident only in the case of steatotic livers, whereas HSP70 and PPAR-γ protein expression were enhanced only in non-steatotic livers. All reported changes were consistent with decreased liver injury diminution, ameliorated hepatic function, and decreased TNF-α and HMGB levels. In addition, the oxidative stress and mitochondrial damage were efficiently prevented by the IGL-1 + TMZ use.es_ES
dc.description.abstract[Conclusions] SIRT1 is associated with HMGB1 decreases and increased autophagy in steatotic livers, contributing to increased tolerance to cold IRI.es_ES
dc.description.sponsorshipThis work was supported by Instituto de Salud Carlos III (ISCIII) through the FIS project PI12/0056, co-funded by FEDER from Regional Development European Funds (European Union).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.titleCross-talk between sirtuin 1 and high-mobility box 1 in steatotic liver graft preservationes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.transproceed.2017.01.071-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.transproceed.2017.01.071es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeartículo-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
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