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Título

Transcriptional changes in human Caco-2 colon cancer cells following exposure to a recurrent non-toxic dose of polyphenol-rich chokeberry juice

AutorBermúdez-Soto, María José ; Larrosa, Mar ; Garcia-Cantalejo, Jesús M.; Espín de Gea, Juan Carlos ; Tomás Barberán, Francisco; García-Conesa, María Teresa
Palabras claveColon cancer
Caco-2
Polyphenols
Chokeberry
Aronia Melanocarpa
Microarrays
Gene expression
Fecha de publicación19-sep-2007
EditorSpringer
CitaciónGenes and Nutrition 2(1): 111-113 (2007)
ResumenBerries and red fruits are important dietary sources of polyphenols [1]. In vitro and animal studies have demonstrated the bioavailability and the anti-proliferative and anticarcinogenic properties of these fruits or of their phenolic components [2, 3]. Consumption of berries may contribute to the reduction of colon cancer by mechanisms not yet understood. Gene expression analysis using microarrays allows for a more comprehensive study of the possible molecular mechanisms by which food or food components may prevent certain cancers of the gastrointestinal tract [4]. The aim of this research is to investigate the anti-proliferative effects of a polyphenol-rich berry juice on a human model of colon cancer cells and its association to transcriptional changes in relation to colon cancer.
Descripción3 pages.-- Printed version published Oct 2007.
Versión del editorhttp://dx.doi.org/10.1007/s12263-007-0026-5
URIhttp://hdl.handle.net/10261/17727
DOI10.1007/s12263-007-0026-5
ISSN1555-8932 (Print)
1865-3499 (Online)
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