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NLCs as a potential carrier system for transdermal delivery of forskolin

AuthorsLasoń, Elwira; Soláns, Conxita; Llinàs, Meritxell; Ogonowski, Jan
Nanostructured lipid carrier
Skin permeation
Issue Date15-Sep-2018
PublisherPolish Biochemical Society
CitationActa Biochimica Polonica
AbstractNanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/ PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin. © by Pawel Pomorski and Polish Biochemical Society 2015.
Publisher version (URL)https://doi.org/10.18388/abp.2018_2554
Appears in Collections:(IQAC) Artículos
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