English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/176954
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorPedret, Annaes_ES
dc.contributor.authorFernandez-Castillejo, Saraes_ES
dc.contributor.authorValls, Rosa-Mariaes_ES
dc.contributor.authorCatalán, Úrsulaes_ES
dc.contributor.authorRubió, Lauraes_ES
dc.contributor.authorRomeu, Martaes_ES
dc.contributor.authorMacià, Albaes_ES
dc.contributor.authorLópez de las Hazas, M. C.es_ES
dc.contributor.authorFarràs, Martaes_ES
dc.contributor.authorGiralt, Montsees_ES
dc.contributor.authorMosele, Juana I.es_ES
dc.contributor.authorMartín-Pelaez, Sandraes_ES
dc.contributor.authorRemaley, Alan T.es_ES
dc.contributor.authorCovas, María Isabeles_ES
dc.contributor.authorFitó, Montserrates_ES
dc.contributor.authorMotilva, Maria-Josées_ES
dc.contributor.authorSolá, Rosaes_ES
dc.identifier.citationMolecular Nutrition and Food Research 62(16): 1800456 (2018)es_ES
dc.description.abstract[Scope] The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol‐enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work.es_ES
dc.description.abstract[Methods and results] VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double‐blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg−1), FVOO (500 mg kg−1), and FVOOT (500 mg kg−1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat‐soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol‐enriched VOOs. These insights support the beneficial effects of OO and PC from different sources.es_ES
dc.description.abstract[Conclusion] Novel therapeutic strategies should increase HDL‐cholesterol levels and enhance HDL functionality. The tailoring of phenol‐enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals.es_ES
dc.description.sponsorshipThis work was supported by grants: the VOHF Study (AGL2009-13517- C03) and the MEFOPC Project (AGL2012-40144-C03) from the Spanish Ministry of Education and Science. The authors wish to acknowledge the support of the IISPV, the EURECAT-CTNS, and the COS; Reus, Spain. M.C.L.H has predoctoral student grant from the Universitat de Lleida. A.P. has Torres Quevedo contract (Subprograma Estatal de Incorporaci´on, Plan Estatal de Investigaci´on Cient´ıfica y T´ecnica y de Innovaci´on). L.R. and M.F. have Sara Borrell postdoctoral grants (CD14/00275, 2015–2017;CD17/00233, 2018–2021). M.F. was also supported by a joint contract of the ISCIII and Health Department of the Catalan Government (CES12/025; CB06/03/0028). U.C. has a PERIS post-doctoral grant ´ (SLT002/16/00239; Catalunya, Spain). NFOC-Salut group is a consolidated research group of Generalitat de Catalunya, Spain (2017 SGR 522).CIBERDEM and CIBEROBN are initiatives of ISCIII of Spain which is supported by FEDER funds (CB06/03).es_ES
dc.publisherJohn Wiley & Sonses_ES
dc.subjectHDL functionalityes_ES
dc.subjectPhenolic compoundses_ES
dc.subjectVirgin olive oiles_ES
dc.titleCardiovascular benefits of phenol-enriched virgin olive oils: new insights from the virgin olive oil and HDL functionality (VOHF) studyes_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.contributor.funderInstitut d'Investigació Sanitària Pere Virgilies_ES
dc.contributor.funderCentre Tecnològic de Catalunyaes_ES
dc.contributor.funderUniversidad de Lleidaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)es_ES
dc.contributor.funderCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show simple item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.