English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/176654
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Post-transcriptional regulation by cytosine-5 methylation of RNA

AuthorsGarcía-Vílchez, Raquel; Sevilla Hernández, Ana ; Blanco, Sandra
RNA methylation
Post-transcriptional regulation
Issue Date2018
CitationBBA - Gene Regulatory Mechanisms 1862(3): 240-252 (2018)
AbstractThe recent advent of high-throughput sequencing technologies coupled with RNA modifications detection methods has allowed the detection of RNA modifications at single nucleotide resolution giving a more comprehensive landscape of post-transcriptional gene regulation pathways. In this review, we focus on the occurrence of 5-methylcytosine (m5C) in the transcriptome. We summarise the main findings of the molecular role in post-transcriptional regulation that governs m5C deposition in RNAs. Functionally, m5C deposition can regulate several cellular and physiological processes including development, differentiation and survival to stress stimuli. Despite many aspects concerning m5C deposition in RNA, such as position or sequence context and the fact that many readers and erasers still remain elusive, the overall recent findings indicate that RNA cytosine methylation is a powerful mechanism to post-transcriptionally regulate physiological processes. In addition, mutations in RNA cytosine-5 methyltransferases are associated to pathological processes ranging from neurological syndromes to cancer.
Publisher version (URL)https://doi.org/10.1016/j.bbagrm.2018.12.003
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
postransRNA.pdf Embargoed until December 27, 20192,17 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.