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Characterization of Vicia (Fabaceae) seed water extracts with potential immunomodulatory and cell antiproliferative activities

AuthorsMegías, Cristina ; Cortés-Giraldo, Isabel ; Girón-Calle, Julio ; Alaíz Barragán, Manuel ; Vioque, Javier
KeywordsFree amino acids
Nitric oxide
Issue DateOct-2018
PublisherJohn Wiley & Sons
CitationJournal of Food Biochemistry 42 (5): e12578 (2018)
AbstractVicia seeds represent an underutilized source of nutritional and functional components. Besides being rich in proteins, they are also rich in polyphenols, free amino acids, and lectins. These components are enriched in a by‐product of the production of protein isolates, a pH 4 soluble extract. Extracts from six Vicia have been analyzed, and NO radical scavenging and antiproliferative activities have been determined. Canavanine was the main free amino acid, while gallic acid derivatives were the most abundant of polyphenols. Fractionation of the extracts by ultrafiltration rendered a lectin‐free fraction that exhibited nitric oxide radical scavenging activity. Based on this activity, and in the presence of high levels of polyphenols and canavanine that are inhibitors of inducible nitric oxide synthase, it is proposed that these extracts may have an immunomodulatory effect. In addition, some extracts inhibited proliferation of cancerous Caco‐2 cells, further supporting the potential of Vicia extracts as functional components.
Description30 Páginas.-- 6 Figuras.- 2 Tablas
Publisher version (URL)http://dx.doi.org/10.1111/jfbc.12578
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