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Título

Effects of 17β-estradiol exposure in the mussel Mytilus galloprovincialis

AutorJaner, Gemma; Lavado Parra, Ramón; Thibaut, Rémi; Porte Visa, Cinta
Palabras claveEstradiol
Mytilus galloprovincialis
P450-aromatase
Esterification
Fecha de publicación4-may-2004
EditorElsevier
CitaciónMarine Environmental Research 58(2-5): 443-446 (2004)
ResumenMussels Mytilus galloprovincialis were exposed to different concentrations of estradiol (20, 200, and 2000 ng/l) in a semi-static regime (1-day dosing intervals) for up to 7 days in an attempt to see how mussels dealt with exogenous estrogenic compounds. Sex hormone levels were determined in whole tissue. Free-estradiol was only significantly elevated at the highest exposure dose (up to 10-fold). Most of the estradiol was in the tissues as fatty acid esters (>78%), which sharply increased in a dose-dependent manner (from 4 ng/g in controls to 258 ng/g at the high exposure group). In contrast, neither free nor esterified testosterone levels showed significant differences between control and exposure groups. The results suggest the existence of mechanisms that allow mussels to maintain their hormonal status, and the important role that fatty acid esterification may play within those mechanisms. Synthesis and conjugation rates of estradiol were further investigated by measuring the activity of P450 aromatase, and palmitoyl-CoA:estradiol acyltransferase, in digestive gland microsomal fractions. Overall, the study contributes to the better knowledge of molluscan endocrinology, and defines new mechanisms of regulation of free steroid-levels in mussels.
Descripción4 pages, 2 figures.-- PMID: 15178065 [PubMed].-- Printed version published in issue Aug-Dec 2004.-- Issue title: "Twelfth International Symposium on Pollutant Responses in Marine Organisms" (Tampa Bay, FL, United States, May 9-13, 2003).
Versión del editorhttp://dx.doi.org/10.1016/j.marenvres.2004.03.028
URIhttp://hdl.handle.net/10261/17645
DOI10.1016/j.marenvres.2004.03.028
ISSN0141-1136 (Print)
1879-0291 (Online)
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