Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/17632
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats

AuthorsHorcajada, M. N.; Habauzit, V.; Trzeciakiewicz, A.; Morand, Christine; Gil-Izquierdo, Ángel CSIC ORCID; Mardon, J.; Lebecque, P.; Davicco, M. J.; Chee, W. S. S.; Coxam, V.; Offord, E.
KeywordsBone growth
Bone sparing effect
Bone mineral density
Polyphenols
Issue Date3-Jan-2008
PublisherAmerican Physiological Society
CitationJournal of Applied Physiology 104(6): 648-654 (2008)
AbstractThe main aim of this study was to investigate the bone-sparing effect of hesperidin, one of the main flavonoid present in oranges, in two age groups of ovariectomized female rats, compared with their intact controls. Young (3 mo) and adult (6 mo) female Wistar rats were sham operated (SH) or ovariectomized (OVX) and then pair-fed for 90 days a casein-based diet supplemented or not with 0.5% hesperidin (Hp; n = 10/group). In older rats, Hp intake led to a partial inhibition of OVX-induced bone loss, whereas a complete inhibition was obtained in younger animals. At both ages, while plasma osteocalcin concentrations were unchanged, urinary excretion of deoxypyridinoline was reduced by Hp intake, suggesting that Hp was able to slow down bone resorption. Unexpectedly, in intact young rats, Hp consumption resulted in a significant increase in bone mineral density (BMD). Indeed, 6-mo-old HpSH rats had a similar BMD to 9-mo-old nontreated SH adult rats, suggesting an accelerated bone mass gain in the young rats. In contrast, in intact adult rats, Hp did not further increase BMD but did improve their bone strength. The results of this study show a protective effect of Hp on bone loss in OVX rats of both ages without uterine stimulation and accompanied by a lipid-lowering effect. The unexpected and intriguing findings obtained in intact rats showing improved BMD in young rats and improved femoral load in adult rats merit further investigation. The bone and lipid benefits of hesperidin make it an attractive dietary agent for the management of the health of postmenopausal women.
Description7 pages, 3 tables, 1 figure.
Publisher version (URL)http://dx.doi.org/10.1152/japplphysiol.00441.2007
URIhttp://hdl.handle.net/10261/17632
DOI10.1152/japplphysiol.00441.2007
ISSN0021-8987
Appears in Collections:(CEBAS) Artículos

Show full item record
Review this work

SCOPUSTM   
Citations

76
checked on May 17, 2022

WEB OF SCIENCETM
Citations

67
checked on May 20, 2022

Page view(s)

312
checked on May 21, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.