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Structure of the yeast mitochondrial large ribosomal subunit

AuthorsAmunts, Alexey; Brown, Alan; Bai, Xiao-chen; Llácer, José Luis ; Hussain, Tanweer; Emsley, Paul; Long, Fei; Murshudov, Garib; Scheres, Sjors H.W.; Ramakrishnan, V.
Issue Date28-Mar-2014
PublisherAmerican Association for the Advancement of Science
CitationScience - AAAS - Incl Science Now - for ABM Norwegian Consortia only - Internet 343(6178):1485-1489 (2014)
AbstractMitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.
Description6 páginas, 6 figuras. Contiete material suplementario
Publisher version (URL)http://dx.doi.org/10.1126/science.1249410
Appears in Collections:(IBV) Artículos
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