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Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles

Other TitlesProcedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor
AuthorsDelgado López, José Manuel ; Gómez-Morales, J.; Fernández Penas, Raquel; Iafisco, Michele; Tampieri, Anna; Panseri, Silvia
Issue Date23-Oct-2018
CitationUS10105390 B2
AbstractProcess for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.
Appears in Collections:(IACT) Patentes
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