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2-Tridecanone impacts surface-associated bacterial behaviours and hinders plant-bacteria interactions

AuthorsLópez-Lara, Isabel M.; Nogales, Joaquina; Pech-Canul, Ángel de la Cruz; Calatrava-Morales, Nieves; Bernabéu-Roda, Lydia; Durán, Paloma; Cuellar, Virginia; Olivares Pascual, José; Alvarez, L.; Palenzuela-Bretones, D.; Romero, M.; Heeb, S.; Cámara, Miguel; Geiger, Otto; Soto, María José
Issue Date2018
PublisherBlackwell Publishing
CitationEnvironmental Microbiology 20: 2049- 2065 (2018)
AbstractSurface motility and biofilm formation are behaviours which enable bacteria to infect their hosts and are controlled by different chemical signals. In the plant symbiotic alpha-proteobacterium Sinorhizobium meliloti, the lack of long-chain fatty acyl-coenzyme A synthetase activity (FadD) leads to increased surface motility, defects in biofilm development and impaired root colonization. In this study, analyses of lipid extracts and volatiles revealed that a fadD mutant accumulates 2-tridecanone (2-TDC), a methylketone (MK) known as a natural insecticide. Application of pure 2-TDC to the wild-type strain phenocopies the free-living and symbiotic behaviours of the fadD mutant. Structural features of the MK determine its ability to promote S. meliloti surface translocation, which is mainly mediated by a flagella-independent motility. Transcriptomic analyses showed that 2-TDC induces differential expression of iron uptake, redox and stress-related genes. Interestingly, this MK also influences surface motility and impairs biofilm formation in plant and animal pathogenic bacteria. Moreover, 2-TDC not only hampers alfalfa nodulation but also the development of tomato bacterial speck disease. This work assigns a new role to 2-TDC as an infochemical that affects important bacterial traits and hampers plant-bacteria interactions by interfering with microbial colonization of plant tissues.
Publisher version (URL)https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.14083
Identifiersdoi: 10.1111/1462-2920.14083
issn: 1462-2912
Appears in Collections:(EEZ) Artículos
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