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Impact of a sustained consumption of grape extract on digestion, gut microbial metabolism and intestinal barrier in broiler chickens

AuthorsChamorro, Susana ; Romero, Carlos ; Brenes, Agustín ; Sánchez-Patán, Fernando ; Bartolomé, Begoña ; Viveros, Agustín; Arija, I.
KeywordsGrape polyphenols
Gut morphology
Gut microbiota
Microbial-phenolic metabolite
Issue Date2019
PublisherRoyal Society of Chemistry
CitationFood and Function 10(3): 1444-1454 (2019)
AbstractThe effect of dietary supplementation with grape extract (GE) at 2.5 and 5.0 g/kg of feed on intestinal utilization of polyphenols and gut health of broiler chickens was determined. The ileal digestibility of grape polyphenols was higher for flavan-3-ol monomers [(+)-catechin and (-)-epicatechin] than for dimers (Procyanidins B1 and B2) and galloylated compounds [(-)-epicatechingallate] and no differences among 2.5 and 5.0 g GE /kg dietary treatments were observed. Excreta concentration of benzoic, phenylacetic, phenylpropionic, cinnamic acids and phenyl-γ-valerolactones phenolic metabolites was higher in birds fed GE, confirming hence microbial metabolism of grape polyphenols at a relevant extent. Gut morphology and total ileal mucin content were not modified by dietary inclusion of GE, but a lower sialic acid concentration was observed in those birds fed the higher concentration of GE. Escherichia coli and lactic-acid bacteria ileal counts were reduced in birds fed GE. Overall, these results prove extensive intestinal utilization and microbial metabolism of grape polyphenols in broiler chickens. Some antimicrobial and mucin-modulation effects were also observed after a sustained consumption of grape polyphenols during 21 days.
Publisher version (URL)https://doi.org/10.1039/C8FO02465K
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