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Substituted isatins and the therapeutic applications thereof for the treatment of neurodegenerative diseases

Other TitlesIsatinas sustituidas y sus aplicaciones terapéuticas para el tratamiento de enfermedades neurodegenerativas
AuthorsMartínez, Ana ; Gil, Carmen ; García Salado, Irene; Pérez Fernández, Daniel Ignacio
Issue Date8-Oct-2015
CitationWO2015150612 A1
Abstract[EN] The invention relates to a family of differently substituted isatins that exhibit activity inhibiting the protein kinase with leucine-rich repeats (LRRK2), such that they are useful in the treatment of diseases mediated by said enzyme, such as inflammatory diseases, autoimmune diseases and neurodegenerative diseases, especially Parkinson's disease.
[ES] La presente invencion se refiere a una familia de isatinas diferentemente sustituidas que presentan actividad inhibitoria de la protema quinasa con repeticiones ricas en leucina (LRRK2) , por lo que son utiles para el tratamiento de las enfermedades mediadas por esta enzima, como las enfermedades inflamatorias, las autoinmunes y las enfermedades neurodegenerativas, especialmente la enfermedad de Parkinson.
Appears in Collections:(IQM) Patentes
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