English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/175331
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations

AuthorsFares, Mario A. ; Sabater-Muñoz, Beatriz; Toft, Christina
KeywordsExpression genome hotspots
Genetic redundancy
Phenotypic plasticity
Environmental stress
Mutational genome hotspots
Gene duplication
Issue Date1-May-2017
PublisherOxford University Press
CitationGenome Biology and Evolution 9(5): 1229-1240 (2017)
AbstractGene duplication generatesnewgeneticmaterial,which has been shownto lead tomajor innovations in unicellular andmulticellular organisms.Awhole-genome duplication occurred in the ancestor of Saccharomyces yeast species but 92%of duplicates returned to single-copy genes shortly after duplication. The persisting duplicated genes in Saccharomyces led to the origin of major metabolic innovations, which have been the source of the unique biotechnological capabilities in the Baker's yeast Saccharomyces cerevisiae. What factors have determined the fate of duplicated genes remains unknown. Here,we report the first demonstration that the local genome mutation and transcription rates determine the fate of duplicates. We show, for the first time, a preferential location of duplicated genes inthemutational and transcriptional hotspotsof S. cerevisiae genome. The mechanism of duplicationmatters,with whole-genome duplicates exhibiting different preservation trends compared to small-scale duplicates. Genome mutational and transcriptional hotspots are rich in duplicates with large repetitive promoter elements. Saccharomyces cerevisiae shows more tolerance to deleterious mutations in duplicates with repetitive promoter elements,which in turn exhibit higher transcriptional plasticity against environmental perturbations. Our data demonstrate that the genome traps duplicates through the accelerated regulatory and functional divergence of their gene copies providing a source of novel adaptations in yeast.
Publisher version (URL)http://doi.org/10.1093/gbe/evx085
Identifiersdoi: 10.1093/gbe/evx085
e-issn: 1759-6653
Appears in Collections:(I2SysBio) Artículos
(IATA) Artículos
(IBMCP) Artículos
Files in This Item:
File Description SizeFormat 
genome_mutational_Fares .pdf625,73 kBUnknownView/Open
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.