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Título

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

AutorAcloque, Hervé; Adams, Meghan S.; Fishwick, Katherine; Bronner-Fraser, Marianne; Nieto, M. Ángela
Fecha de publicación1-jun-2009
EditorAmerican Society for Clinical Investigation
CitaciónJournal of Clinical Investigation 119(6): 1438-1449 (2009)
ResumenThe events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.
Descripción12 pages.-- PMID: 19487820 [PubMed].
Versión del editorhttp://dx.doi.org/10.1172/JCI38019
URIhttp://hdl.handle.net/10261/17496
DOI10.1172/JCI38019
ISSN0021-9738
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