Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/174734
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Interactomics and tick vaccine development: new directions for the control of tick-borne diseases

AutorArtigas-Jerónimo, Sara CSIC ORCID; Fuente, José de la CSIC ORCID ; Villar, Margarita CSIC ORCID
Palabras claveTick
Interactomics
Tick-borne diseases
Vaccine
Fecha de publicación2018
EditorTaylor & Francis
CitaciónExpert Review of Proteomics 15(8): 627-635 (2018)
Resumen[Introduction]: Ticks are obligate hematophagous arthropod ectoparasites that transmit pathogens responsible for a growing number of tick-borne diseases (TBDs) throughout the world. Vaccines have been shown to be the most efficient, cost-effective, and environmentally friendly approach for the control of ticks and the prevention of TBDs. Although at its infancy, interactomics has shown the possibilities that the knowledge of the interactome offers in understanding tick biology and the molecular mechanisms involved in pathogen infection and transmission. Furthermore, interactomics has provided information for the identification of candidate vaccine protective antigens. [Areas covered]: In this special report, we review the different approaches used for the study of protein–protein physical and functional interactions, and summarize the application of interactomics to the characterization of tick biology and tick–host–pathogen interactions, and the possibilities that offers to vaccine development for the control of ticks and TBDs. [Expert commentary]: The combination of interacting proteins in antigen formulations may increase vaccine efficacy. In the near future, the combination of interactomics with other omics approaches such as transcriptomics, proteomics, metabolomics, and regulomics together with intelligent Big Data analytic techniques will improve the high throughput discovery and characterization of vaccine protective antigens for the prevention and control of TBDs.
URIhttp://hdl.handle.net/10261/174734
DOI10.1080/14789450.2018.1506701
Identificadoresdoi: 10.1080/14789450.2018.1506701
e-issn: 1744-8387
issn: 1478-9450
Aparece en las colecciones: (IREC) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

9
checked on 27-mar-2024

SCOPUSTM   
Citations

14
checked on 21-mar-2024

WEB OF SCIENCETM
Citations

13
checked on 26-feb-2024

Page view(s)

196
checked on 29-mar-2024

Download(s)

67
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.