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Title

Inbreeding shapes tuberculosis progression in female adult badgers (Meles meles)

AuthorsQueirós, João ; Vicente, Joaquín
Issue Date2018
PublisherJohn Wiley & Sons
British Ecological Society
CitationJournal of Animal Ecology 87(6): 1497-1499 (2018)
AbstractIncreasing crossbreeding of relatives promotes inbreeding which, in turn, can cause a reduction in fitness and the emergence of a phenomenon known as inbreeding depression. Benton et al., used the badger (Meles meles)—Mycobacterium bovis model system to study the relationship between inbreeding, disease, ageing and sex. A link between multilocus homozygosity (general effect) and TB progression (measured as antibody response to infection) and between homozygosity at specific loci (local effect) and TB progression were established in this study, highlighting the importance of host genetic background in determining host disease outcomes, and thus on shaping disease dynamics in wild populations. Moreover, the authors demonstrated for the first time in a natural population that this positive association might be modulated by sex and age. In infected individuals, inbreeding only affects disease progression in adult females.
URIhttp://hdl.handle.net/10261/174728
Identifiersdoi: 10.1111/1365-2656.12901
e-issn: 1365-2656
issn: 0021-8790
Appears in Collections:(IREC) Artículos
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