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http://hdl.handle.net/10261/174724
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dc.contributor.author | Díez-Delgado, Iratxe | - |
dc.contributor.author | Sevilla, Iker A. | - |
dc.contributor.author | Romero, Beatriz | - |
dc.contributor.author | Tanner, Eleanor | - |
dc.contributor.author | Barasona, José A. | - |
dc.contributor.author | White, Andrew R. | - |
dc.contributor.author | Lurz, Peter W. W. | - |
dc.contributor.author | Boots, Mike | - |
dc.contributor.author | Fuente, José de la | - |
dc.contributor.author | Domínguez, Lucas | - |
dc.contributor.author | Vicente, Joaquín | - |
dc.contributor.author | Garrido, Joseba M. | - |
dc.contributor.author | Juste, Ramón A. | - |
dc.contributor.author | Aranaz, Alicia | - |
dc.contributor.author | Gortázar, Christian | - |
dc.date.accessioned | 2019-01-25T09:41:10Z | - |
dc.date.available | 2019-01-25T09:41:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1016/j.prevetmed.2018.04.002 | - |
dc.identifier | issn: 0167-5877 | - |
dc.identifier | e-issn: 1873-1716 | - |
dc.identifier.citation | Preventive Veterinary Medicine 155: 11-20 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/174724 | - |
dc.description.abstract | The Eurasian wild boar (Sus scrofa) is the main wild reservoir of the Mycobacterium tuberculosis complex in Mediterranean woodlands and a key risk factor for cattle tuberculosis (TB) breakdowns. Wild boar vaccination therefore has the potential to be a valuable tool for TB control. We tested two orally delivered vaccines, heat-inactivated Mycobacterium bovis (IV) and BCG, in four sites (two per vaccine type: one Managed and one Natural or unmanaged) during four years. TB was also monitored in 15 unvaccinated sites (spatial control), as well as in all sites from one year prior to intervention (temporal control). The rationale is that by vaccinating 2–6 month old wild boar piglets we can reduce disease at the population level during the study period. This is achievable due to the fast turnover of wild boar populations. Vaccine baits were deployed using selective piglet feeders and this method proved highly successful with uptake rates of 50 to 74% in Natural sites and 89 to 92% in Managed sites. This is relevant for the potential delivery of vaccines to control other diseases, too. Local wild boar TB prevalence at the beginning of the study was already high ranging from 50 to 100%. TB prevalence increased in unvaccinated sites (6%), while a significant decline occurred in the Managed IV site (34%). Changes recorded in the remaining sites were not significant. The short-term impact of vaccination observed in the field was complemented by mathematical modelling, representative of the field system, which examined the long-term impact and showed that vaccination of piglets reduced prevalence and increased abundance at the population level. We conclude that IV could become part of integrated TB control schemes, although its application must be tailored for each specific site. | - |
dc.description.sponsorship | This is a contribution to Plan Nacional I+D+i AGL2014-56305 from MINECO and EU FEDER, and to the EU–FP7 grant WildTBVac. E. Tanner was supported by The Maxwell Institute Graduate School in Analysis and its Applications, a Centre for Doctoral Training funded by the UK Engineering and Physical Sciences Research Council (grant EP/L016508/01), the Scottish Funding Council, Heriot-Watt University and the University of Edinburgh. I. Díez-Delgado was supported by a predoctoral grant from MINECO. | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/613779 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-56305-C3-1-R | - |
dc.rights | closedAccess | - |
dc.subject | Epidemiological modelling | - |
dc.subject | Heat-inactivated Mycobacterium bovis | - |
dc.subject | Field vaccination | - |
dc.subject | BCG | - |
dc.subject | Wild boar | - |
dc.subject | Tuberculosis control | - |
dc.title | Impact of piglet oral vaccination against tuberculosis in endemic free-ranging wild boar populations | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.prevetmed.2018.04.002 | - |
dc.date.updated | 2019-01-25T09:41:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Scottish Funding Council | - |
dc.contributor.funder | University of Edinburgh | - |
dc.contributor.funder | Engineering and Physical Sciences Research Council (UK) | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000360 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000848 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000266 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 29786520 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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