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Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

AuthorsGrijalvo, Santiago CSIC ORCID; Puras, Gustavo; Zárate, Jon; Sainz-Ramos, Myriam; Qtaish, Nuseibah A. L.; López, Tania; Mashal, Mohamed; Attia, Noha; Díaz, David; Pons Pons, Ramon; Fernández, Eduardo; Pedraz, Jose Luis; Eritja Casadellà, Ramón CSIC ORCID
KeywordsAntisense oligonucleotides
Cationic lipids
Cationic niosomes
Gene delivery
Small interference RNA
Issue Date22-Jan-2019
PublisherMolecular Diversity Preservation International
CitationPharmaceutics 11(2), 50 (2019)
AbstractCationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).
Publisher version (URL)https://doi.org/10.3390/pharmaceutics11020050
Appears in Collections:(IQAC) Artículos
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