English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/174625
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Different lesion distribution in calves orally or intratracheally challenged with Mycobacterium bovis: implications for diagnosis

AutorSerrano, Miriam; Sevilla, Iker A.; Fuertes, Miguel; Geijo, Mariví; Risalde, María Ángeles; Ruiz Fons, Francisco ; Gortázar, Christian ; Juste, Ramón A.; Domínguez, Lucas; Elguezabal, Natalia; Garrido, Joseba M.
Fecha de publicación2018
EditorBioMed Central
CitaciónVeterinary Research 49(1): 74 (2018)
ResumenAnimal tuberculosis (TB) remains a major problem in some countries despite the existence of control programmes focused mainly on cattle. In this species, aerogenous transmission is accepted as the most frequent infection route, affecting mainly the respiratory system. Under the hypothesis that the oral route could be playing a more relevant role in transmission, diagnosis and disease persistence than previously thought, this study was performed to assess the course of TB infection in cattle and its effects on diagnosis depending on the route of entry of Mycobacterium bovis. Two groups of five calves each were either endotracheally (EC) or orally (OC) challenged. Necropsies were carried out 12 weeks after challenge except for three OC calves slaughtered 8 weeks later. All animals reacted to the tuberculin skin test and the entire EC group was positive to the interferon-gamma release assay (IGRA) 2 weeks after challenge and thereafter. The first positive IGRA results for OC calves (3/5) were recorded 4 weeks after challenge. Group comparison revealed significant differences in lesion and positive culture location and scoring. TB-compatible gross lesions and positive cultures were more frequently found in the thorax (p < 0.001) and lung (p < 0.05) of EC animals, whereas OC animals presented lesions (p = 0.23) and positive cultures (p < 0.05) mainly located in the abdomen. These results indicate that the infection route seems to be a determining factor for both the distribution and the time needed for the development of visible lesions. Our study suggests that confirmation of TB infection in some skin reactor animals can be problematic if current post-mortem examination and diagnostics are not improved.
Versión del editorhttps://doi.org/10.1186/s13567-018-0566-2
Identificadoresdoi: 10.1186/s13567-018-0566-2
e-issn: 1297-9716
issn: 0928-4249
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
diffediag.pdf1,2 MBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.