Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/174609
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors |
Autor: | Aparicio, David CSIC ORCID ; Torres-Puig, Sergi; Ratera, Mercè CSIC ORCID; Querol, Enrique; Piñol, Jaume; Pich, Oscar Q.; Fita, Ignacio CSIC ORCID | Fecha de publicación: | 26-oct-2018 | Editor: | Nature Publishing Group | Citación: | Nature Communications 9: 4471 (2018) | Resumen: | Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the cell membrane. Herein, we present the crystal structures of the extracellular region of the virulence factor P110 (916 residues) unliganded and in complex with sialic acid oligosaccharides. P110 interacts only with the neuraminic acid moiety of the oligosaccharides and experiments with human cells demonstrate that these interactions are essential for mycoplasma cytadherence. Additionally, structural information provides a deep insight of the P110 antigenic regions undergoing programmed variation to evade the host immune response. These results enlighten the interplay of M. genitalium with human target cells, offering new strategies to control mycoplasma infections. | Versión del editor: | https://doi.org/10.1038/s41467- 018-06963-y | URI: | http://hdl.handle.net/10261/174609 | DOI: | 10.1038/s41467-018-06963-y | E-ISSN: | 2041-1723 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Mycoplasma_Aparicio.pdf | 3,63 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
19
checked on 17-abr-2024
SCOPUSTM
Citations
26
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
25
checked on 26-feb-2024
Page view(s)
243
checked on 24-abr-2024
Download(s)
208
checked on 24-abr-2024