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Characterization of quality of sediments from Paranaguá Bay (Brazil) by combined in vitro bioassays and chemical analyses

AuthorsRizzi, Juliane; Pérez-Albaladejo, Elisabet; Fernandes, Denise; Contreras, Javier; Froehner, Sandro José; Porte Visa, Cinta
Endocrine disruption
In vitro bioassays
Organic pollutants
Sediment contamination
Issue DateJul-2017
CitationEnvironmental Toxicology and Chemistry 36 (7): 1811-1819 (2017)
AbstractThe present study characterizes the quality of sediments from the Paranaguá Estuarine Complex (South Brazil). Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) were determined in sediment samples together with a series of different in vitro bioassays. The fish hepatoma cell line (PLHC-1) was used to determine the presence of cytotoxic compounds and CYP1A- and oxidative stress-inducing agents in sediment extracts. Ovarian microsomal fractions from sea bass (Dicentrarchus labrax) were used to detect the presence of endocrine disrupters that interfered with the synthesis of estrogens (ovarian CYP19). Despite the relatively low levels of pollutants and no evidence of negative effects based on guideline levels, sediments collected close to harbors were enriched with CYP1A-inducing agents and they showed higher cytotoxicity. In contrast, sediments from internal areas inhibited CYP19 activity, which suggests the presence of endocrine disrupters at these sites. Overall, the selected bioassays and the chemistry data led to the identification of potentially impacted areas along the Paranaguá Estuarine Complex that would require further action to improve their environmental quality. Environ Toxicol Chem 2017;36:1811–1819. © 2016 SETAC. © 2016 SETAC
Publisher version (URL)https://doi.org/10.1002/etc.3553
Appears in Collections:(IDAEA) Artículos
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