Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/174536
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Structural and functional implications of human transforming growth factor b-Induced protein, TGFBIp, in corneal dystrophies

AutorGarcía-Castellanos, Raquel CSIC ORCID; Sukusu Nielsen, Nadia; Runager, Kasper; Thøgersen, Ida B.; Lukassen, Marie V.; Poulsen, Ebbe T.; Goulas, Theodoros CSIC ORCID; Enghild, Jan J.; Gomis-Rüth, F. Xavier CSIC ORCID
Palabras claveCorneal dystrophy
Fasciclin FAS1 domain
Cysteine-rich CROPT domain
Crystal structures
Multi-domain protein
Pathological mutants
Extracellular matrix protein
Fecha de publicación7-nov-2017
EditorElsevier
CitaciónStructure 25(11): 1740-1750.e2 (2017)
ResumenA major cause of visual impairment, corneal dystrophies result from accumulation of protein deposits in the cornea. One of the proteins involved is transforming growth factor β-induced protein (TGFBIp), an extracellular matrix component that interacts with integrins but also produces corneal deposits when mutated. Human TGFBIp is a multi-domain 683-residue protein, which contains one CROPT domain and four FAS1 domains. Its structure spans ∼120 Å and reveals that vicinal domains FAS1-1/FAS1-2 and FAS1-3/FAS1-4 tightly interact in an equivalent manner. The FAS1 domains are sandwiches of two orthogonal four-stranded β sheets decorated with two three-helix insertions. The N-terminal FAS1 dimer forms a compact moiety with the structurally novel CROPT domain, which is a five-stranded all-β cysteine-knot solely found in TGFBIp and periostin. The overall TGFBIp architecture discloses regions for integrin binding and that most dystrophic mutations cluster at both molecule ends, within domains FAS1-1 and FAS1-4
Versión del editorhttps://doi.org/10.1016/j.str.2017.09.001
URIhttp://hdl.handle.net/10261/174536
DOI10.1016/j.str.2017.09.001
ISSN0969-2126
E-ISSN1878-4186
Aparece en las colecciones: (IBMB) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Structural and functional_GarciaCastellanos.pdf11,24 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

24
checked on 25-mar-2024

WEB OF SCIENCETM
Citations

20
checked on 28-feb-2024

Page view(s)

299
checked on 28-mar-2024

Download(s)

297
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.