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Title

Engineering and Applications of fungal laccases for organic synthesis

AuthorsKunamneni, Adinarayana CSIC ORCID; Camarero, Susana CSIC ORCID ; García-Burgos, Carlos CSIC; Plou Gasca, Francisco José CSIC ORCID ; Ballesteros Olmo, Antonio CSIC ORCID; Alcalde Galeote, Miguel CSIC ORCID
KeywordsLaccases
EC 1.10.3.2
Issue Date20-Nov-2008
PublisherBioMed Central
CitationMicrobial Cell Factories 7:32 (2008)
AbstractLaccases are multi-copper containing oxidases (EC 1.10.3.2), widely distributed in fungi, higher plants and bacteria. Laccase catalyses the oxidation of phenols, polyphenols and anilines by one-electron abstraction, with the concomitant reduction of oxygen to water in a four-electron transfer process. In the presence of small redox mediators, laccase offers a broader repertory of oxidations including non-phenolic substrates. Hence, fungal laccases are considered as ideal green catalysts of great biotechnological impact due to their few requirements (they only require air, and they produce water as the only by-product) and their broad substrate specificity, including direct bioelectrocatalysis. Thus, laccases and/or laccase-mediator systems find potential applications in bioremediation, paper pulp bleaching, finishing of textiles, bio-fuel cells and more. Significantly, laccases can be used in organic synthesis, as they can perform exquisite transformations ranging from the oxidation of functional groups to the heteromolecular coupling for production of new antibiotics derivatives, or the catalysis of key steps in the synthesis of complex natural products. In this review, the application of fungal laccases and their engineering by rational design and directed evolution for organic synthesis purposes are discussed.
Description17 pages, 9 figures, 2 tables.
Publisher version (URL)http://dx.doi.org/10.1186/1475-2859-7-32
URIhttp://hdl.handle.net/10261/17439
DOI10.1186/1475-2859-7-32
ISSN1475-2589
Appears in Collections:(ICP) Artículos
(CIB) Artículos

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