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Title

Vaccination against louping Ill virus protects goats from experimental challenge with Spanish goat encephalitis virus

AuthorsSalinas, L. M.; Casais, Rosa; García Marín, Juan Francisco ; Dalton, K. P.; Royo, Luis J.; Cerro, Ana del; Gayo, E.; Dagleish, M. P.; Alberdi, Pilar ; Juste, Ramón A.; Fuente, José de la ; Balseiro, Ana
KeywordsVaccination
Spanish goat encephalitis virus
Experimental infection
Goat
Issue Date2017
PublisherElsevier
CitationJournal of Comparative Pathology 156(4): 409-418 (2017)
AbstractSpanish goat encephalitis virus (SGEV) is a recently described member of the genus Flavivirus belonging to the tick-borne encephalitis group of viruses, and is closely related to louping ill virus (LIV). Naturally acquired disease in goats results in severe, acute encephalitis and 100% mortality. Eighteen goats were challenged subcutaneously with SGEV; nine were vaccinated previously against LIV and nine were not. None of the vaccinated goats showed any clinical signs of disease or histological lesions, but all of the non-vaccinated goats developed pyrexia and 5/9 developed neurological clinical signs, primarily tremors in the neck and ataxia. All non-vaccinated animals developed histological lesions restricted to the central nervous system and consistent with a lymphocytic meningomyeloencephalitis. Vaccinated goats had significantly (P <0.003) greater concentrations of serum IgG and lower levels of IgM (P <0.0001) compared with unvaccinated animals. SGEV RNA levels were below detectable limits in the vaccinated goats throughout the experiment, but increased rapidly and were significantly (P <0.0001) greater 2–10 days post challenge in the non-vaccinated group. In conclusion, vaccination of goats against LIV confers highly effective protection against SGEV; this is probably mediated by IgG and prevents an increase in viral RNA load in serum such that vaccinated animals would not be an effective reservoir of the virus.
URIhttp://hdl.handle.net/10261/174269
Identifiersdoi: 10.1016/j.jcpa.2017.03.004
e-issn: 1532-3129
issn: 0021-9975
Appears in Collections:(IREC) Artículos
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