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Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy

AuthorsRamos, Eva; Romero, Alejandro ; Marco-Contelles, José ; López-Muñoz, Francisco; Pino, Javier del
Issue Date2018
PublisherAmerican Chemical Society
CitationChemical Research in Toxicology 31: 839-842 (2018)
AbstractASS234 is a new multitarget molecule with multiple neuroprotective actions that significantly elevate mRNA levels of NRF2 and HSF1 transcriptional factors and of HSP105, HSP90AB1, HSPA1A, HSPA1B, HSPA5, HSPA8, HSPA9, HSP60, DNAJA1, DNAJB1, DNAJB6, DNAJC3, DNAJC5, DNAJC6, HSPB1, HSPB2, HSPB5, HSPB6, HSPB8, and HSP10 heat shock proteins (HSPs) family members in SH-SY5Y cells. This NRF2 and HSF1 overexpression may explain the upregulation of both the antioxidant enzymes previously described and the members of the HSPs family observed. These findings suggest that ASS234 is a potent HSPs inductor, which might be beneficial for preventing protein misfolding aggregation and cell death in Alzheimer's disease and other neurodegenerative diseases.
Publisher version (URL)http://dx.doi.org/10.1021/acs.chemrestox.8b00192
Identifiersdoi: 10.1021/acs.chemrestox.8b00192
issn: 0893-228X
e-issn: 1520-5010
Appears in Collections:(IQOG) Artículos
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