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Expression of early growth response gene-2 and regulated cytokines correlate with recovery from Guillain-Barré syndrome

AuthorsDoncel-Pérez, Ernesto ; Mateos-Hernández, Lourdes ; Pareja, Eduardo; García-Forcada, Ángel; Villar, Margarita ; Tobes, Raquel; Romero Ganuza, Francisco; Vila del Sol, Virginia; Ramos, Ricardo; Fernández de Mera, Isabel G.; Fuente, José de la
Issue Date2016
PublisherAmerican Association of Immunologists
CitationJournal of Immunology 196(3): 1102-1107 (2016)
AbstractGuillain-Barré syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin to discover possible correlates of disease progression and recovery. The study was then extended using GBS and spinal cord injury unrelated patients with similar medications and healthy individuals. The early growth response gene-2 (EGR2) was upregulated in GBS patients during disease recovery. The results provided evidence for the implication of EGR2 in GBS and suggested a role for EGR2 in the regulation of IL-17, IL-22, IL-28A, and TNF-ß cytokines in GBS patients. These results identified biomarkers associated with GBS recovery and suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of this acute neuropathy.
Identifiersdoi: 10.4049/jimmunol.1502100
issn: 0022-1759
e-issn: 1550-6606
Appears in Collections:(IREC) Artículos
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