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Complement component 3: a new paradigm in tuberculosis vaccine

AuthorsFuente, José de la ; Gortázar, Christian ; Juste, Ramón A.
Issue Date2016
PublisherTaylor & Francis
CitationExpert Review of Vaccines 15(3): 275-277 (2016)
AbstractVaccines are critical for the control of tuberculosis (TB) affecting humans and animals worldwide. First-generation vaccines protect from active TB but new vaccines are required to protect against pulmonary disease and infection. Recent advances in post-genomics technologies have allowed the characterization of host-pathogen interactions to discover new protective antigens and mechanisms to develop more effective vaccines against TB. Studies in the wild boar model resulted in the identification of complement component 3 (C3) as a natural correlate of protection against TB. Oral immunization with heat-inactivated mycobacteria protected wild boar against TB and showed that C3 plays a central role in protection. These results point at C3 as a target to develop novel vaccine formulations for more effective protection against TB in humans and animals.
Identifiersdoi: 10.1586/14760584.2016.1125294
e-issn: 1744-8395
issn: 1476-0584
Appears in Collections:(IREC) Artículos
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