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http://hdl.handle.net/10261/173947
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Title: | Complement component 3: a new paradigm in tuberculosis vaccine |
Authors: | Fuente, José de la ![]() ![]() |
Keywords: | Mycobacteria Vaccine Immunology Complement Tuberculosis |
Issue Date: | 2016 |
Publisher: | Taylor & Francis |
Citation: | Expert Review of Vaccines 15(3): 275-277 (2016) |
Abstract: | Vaccines are critical for the control of tuberculosis (TB) affecting humans and animals worldwide. First-generation vaccines protect from active TB but new vaccines are required to protect against pulmonary disease and infection. Recent advances in post-genomics technologies have allowed the characterization of host-pathogen interactions to discover new protective antigens and mechanisms to develop more effective vaccines against TB. Studies in the wild boar model resulted in the identification of complement component 3 (C3) as a natural correlate of protection against TB. Oral immunization with heat-inactivated mycobacteria protected wild boar against TB and showed that C3 plays a central role in protection. These results point at C3 as a target to develop novel vaccine formulations for more effective protection against TB in humans and animals. |
URI: | http://hdl.handle.net/10261/173947 |
DOI: | 10.1586/14760584.2016.1125294 |
Identifiers: | doi: 10.1586/14760584.2016.1125294 e-issn: 1744-8395 issn: 1476-0584 |
Appears in Collections: | (IREC) Artículos |
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