Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/173538
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | García-Fuente, Amador | - |
dc.contributor.author | Vázquez, Fernando | - |
dc.contributor.author | Viéitez, José M. | - |
dc.contributor.author | García Alonso, F. J. | - |
dc.contributor.author | Martín, José Ignacio | - |
dc.contributor.author | Ferrer, Jaime | - |
dc.date.accessioned | 2018-12-21T12:16:46Z | - |
dc.date.available | 2018-12-21T12:16:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1038/s41598-018-23321-6 | - |
dc.identifier | e-issn: 2045-2322 | - |
dc.identifier.citation | Scientific Reports 8: 4964 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/173538 | - |
dc.description.abstract | The precise determination of dose-effect curves and the combination effect of drugs is of crucial importance in the development of new therapies for the most dreadful diseases. We have found that the current implementations of the theory of Chou et al. are not accurate enough in some circumstances and might lead to erroneous predictions of synergistic or antagonistic behaviour. We have identified the source of inaccuracies and fixed it thereby improving the accuracy of those methods. Here we explain the main features of our approach and demonstrate its higher accuracy as compared to the standard methods. Therefore, this new implementation might have a huge impact in the reliability of future research on new Combination Therapies. | - |
dc.description.sponsorship | This work was supported by FICYT (grant GRUPIN14-121) and by the Spanish MINECO (project FIS2013-45469). | - |
dc.publisher | Nature Publishing Group | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2013-45469-C4-1-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | CISNE: An accurate description of dose-effect and synergism in combination therapies | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/s41598-018-23321-6 | - |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-018-23321-6 | - |
dc.date.updated | 2018-12-21T12:16:46Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100008430 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 29563526 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (CINN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
cisnean.pdf | 1,54 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
17
checked on 16-abr-2024
SCOPUSTM
Citations
36
checked on 11-abr-2024
WEB OF SCIENCETM
Citations
28
checked on 29-feb-2024
Page view(s)
222
checked on 19-abr-2024
Download(s)
185
checked on 19-abr-2024