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Prenatal exposure to persistent organic pollutants and anogenital distance in children at 18 months

AuthorsGarcía-Villarino, Miguel; Riaño-Galán, Isolina; Rodríguez Dehli, Ana Cristina; Vizcaino, Esther; Grimalt, Joan O. ; Tardón, Adonina G.; Fernández-Somoano, Ana
KeywordsDEHP metabolites
Phthalic Acids
Diethylhexyl Phthalate
Issue Date1-Oct-2018
PublisherS. Karger AG
CitationHormone Research in Paediatrics 90(2): 116-122 (2018)
AbstractBackground: Anogenital distance (AGD) is a measure of in utero exposure to hormonally active agents. The aim of the present study was to evaluate the association between prenatal exposure to persistent organic pollutants (POPs) and AGD. Methods: POP levels were measured in pregnant women, and the AGD was recorded in 43 offspring at 18 months. We used linear regression models to analyze the association between maternal POP exposure and offspring AGD. We defined the anogenital index (AGI) as AGD divided by weight at 18 months (AGI = AGD / weight at 18 months [mm/kg]) and included this variable in the regression models. Results: AGI measure was 2.35 (0.61) and 1.38 (0.45) in males and females, respectively. AGI was inversely associated with lipid-adjusted concentrations of PBDE-99 (β = -0.28, 95% confidence interval [CI]: -0.51, -0.04) and PBDE-153 (β = -0.61, 95% CI: -1.11, -0.11) in males. We did not find any statistically significant relationship between any POPs and AGI in females. Conclusions: Environmental exposure to POPs may affect genital development and result in reproductive tract alterations with potentially relevant health consequences in maturity. © 2018 The Author(s). Published by S. Karger AG, Basel.
Publisher version (URL)https://doi.org/10.1159/000492236
Appears in Collections:(IDAEA) Artículos
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