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Title: | Péptidos antihipertensivos derivados de proteínas de leche y huevo |
Other Titles: | Peptides with antihypertensive activity from milk and egg proteins | Authors: | Aleixandre, Amaya; Miguel, Marta CSIC ORCID ; Muguerza, B. | Keywords: | Péptidos bioactivos Hipertensión Enzima convertidora de la angiotensina Leche Huevo Bioactive peptides Hypertension Angiotensin converting enzyme Milk Egg |
Issue Date: | Jul-2008 | Publisher: | Sociedad Española de Nutrición Parenteral y Enteral Aula Médica Ediciones |
Citation: | Nutrición Hospitalaria 23(4): 313-318 (2008) | Abstract: | [ES] Algunos fragmentos de proteínas alimentarias, una vez liberados mediante hidrólisis, pueden producir un descenso del tono arterial. Son importantes los hidrolizados y péptidos provenientes de proteínas lácteas. Destacan los hidrolizados de caseína con tripsina, y los productos antihipertensivos obtenidos por fermentación de la leche con Lactobacillus helveticus. Estos productos contienen secuencias como Val-Pro-Pro (VPP) e Ile-Pro-Pro (IPP), que inhiben la enzima convertidora de la angiotensina (ECA). Algunas cepas de Enterococcus faecalis también producen péptidos antihipertensivos inhibidores de la ECA. Entre estos péptidos destaca la secuencia LHLPLP. Existen asimismo péptidos e hidrolizados antihipertensivos derivados de proteínas de huevo. Podemos citar las secuencias FRADHPFL (ovokinina) y RADHPF (ovokinina 2-7) con actividad vasodilatadora endotelio-dependiente, y algunos hidrolizados de clara de huevo que inhiben la ECA. Los productos mencionados podrían utilizarse como ingredientes en alimentos funcionales. Algunos han probado ya su eficacia y seguridad en pacientes hipertensos. [EN] Antihypertensive hydrolysates and peptides have been isolated from food proteins. Among them, there are of particular interest the antihypertensive casein hydrolysates, and some antihypertensive products obtained when milk was fermented by Lactobacillus helveticus. The sequences Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), with angiotensin-converting enzyme (ACE) inhibitory activity, have been isolated from these fermented products. Selected Enterococcus faecalis strains can also produce milk derived peptides with ACE inhibitory and antihypertensive activities. The main of them is the sequence LHLPLP. Some studies also describe the production of antihypertensive hydrolysates and peptides from egg proteins. The sequences FRADHPFL (ovokinin) and RADHPFL (ovokinin 2-7), that have shown endothelium-dependent vasodilator activity, were obtained at first. Some egg white hydrolysates with ACE inhibitory activity have also been described. The idea of including the abovementioned products as functional food ingredients is particularly attractive. Some of them have already proved their safety and effectiveness in hypertensive patients. |
Description: | 6 páginas, 1 tabla.-- PMID: 18604316 [PubMed]. | Publisher version (URL): | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112008000500002&lng=en&nrm=iso | URI: | http://hdl.handle.net/10261/17288 | ISSN: | 0212-1611 |
Appears in Collections: | (IFTOX) Artículos |
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NutrHosp_23_4_2008.pdf | 128,79 kB | Adobe PDF | ![]() View/Open |
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