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Bioactive compounds produced by gut microbial tannase: implications for colorectal cancer development

AutorLópez de Felipe, Félix ; Rivas, Blanca de las ; Muñoz, Rosario
Palabras claveBioactive compounds
Pyrogallol
Gallic acid
Colorectal cancer
Microbial tannase
Fecha de publicación2017
EditorFrontiers Media
CitaciónBioactive Compounds from Microbes: 39-42 (2017)
SerieFrontiers in Microbiology 5
ResumenThe microorganisms in the human gastrointestinal tract have a profound influence on the transformation of food into metabolites which can impact human health. Gallic acid (GA) and pyrogallol (PG) are bioactive compounds displaying diverse biological properties, including carcinogenic inhibiting activities. However, its concentration in fruits and vegetables is generally low. These metabolites can be also generated as final products of tannin metabolism by microbes endowed with tannase, which opens up the possibility of their anti-cancer potential being increased. Patients with colorectal cancer (CRC) display an imbalanced gut microbiota respect to healthy population.The recent use of next generation sequencing technologies has greatly improved knowledge of the identity of bacterial species that colonize non-tumorous and tumorous tissues of CRC patients.This information provides a unique opportunity to shed light on the role played by gut microorganisms in the different stages of this disease.We here review the recently published gut microbiome associated to CRC patients and highlight tannase as an underlying gene function of bacterial species that selectively colonize tumorous tissues, but not adjacent non-malignant tissues. Given the anti-carcinogenic roles of GA and PG produced by gut tannin-degrading bacteria, we provide an overview of the possible consequences of this intriguing coincidence for CRC development.
DescripciónTrabajo publicado en Diciembre de 2014: Artículo 684.
URIhttp://hdl.handle.net/10261/172523
Identificadoresisbn: 978-2-88945-185-2
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