English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/172455
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export

AuthorsOliete-Calvo, Paula; Serrano-Quílez, Joan; Nuño-Cabanes, Carme; Pérez-Martínez, María E.; Soares, Luis M; Dichtl, Bernhard; Buratowski, Stephen; Pérez-Ortín, José E.; Rodríguez-Navarro, Susana
KeywordsH2B ubiquitination
Epigenetics
mRNA export
Transcription
Yeast
Issue DateNov-2018
PublisherWiley-Blackwell
CitationEMBO Reports 19(11): e45992 (2018)
AbstractMonoubiquitination of histone H2B (to H2Bub1) is required for downstream events including histone H3 methylation, transcription, and mRNA export. The mechanisms and players regulating these events have not yet been completely delineated. Here, we show that the conserved Ran-binding protein Mog1 is required to sustain normal levels of H2Bub1 and H3K4me3 in Saccharomyces cerevisiae Mog1 is needed for gene body recruitment of Rad6, Bre1, and Rtf1 that are involved in H2B ubiquitination and genetically interacts with these factors. We provide evidence that the absence of MOG1 impacts on cellular processes such as transcription, DNA replication, and mRNA export, which are linked to H2Bub1. Importantly, the mRNA export defect in mog1Δ strains is exacerbated by the absence of factors that decrease H2Bub1 levels. Consistent with a role in sustaining H2Bub and H3K4me3 levels, Mog1 co-precipitates with components that participate in these modifications such as Bre1, Rtf1, and the COMPASS-associated factors Shg1 and Sdc1. These results reveal a novel role for Mog1 in H2B ubiquitination, transcription, and mRNA biogenesis.
Description17 páginas, 12 figuras.
Publisher version (URL)http://dx.doi.org/10.15252/embr.201845992
URIhttp://hdl.handle.net/10261/172455
DOI10.15252/embr.201845992
ISSN1469-221X
E-ISSN1469-3178
Appears in Collections:(IBV) Artículos
Files in This Item:
File Description SizeFormat 
2018-Rodriguez-Navarro-EMBOR-.pdf19,89 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.