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Colonic flavanol metabolites protect pancreatic and endothelial cells against oxidative stress-induced cell damage

AuthorsÁlvarez-Cilleros, David; Fernández-Millán, Elisa; Escrivá, Fernando; Goya, Luis ; Ramos, Sonia ; Álvarez, Carmen; Martín, M. Ángeles
Issue Date2017
CitationReunión anual CIBERDEM 2017
AbstractOxidative stress has been implicated in the progressive dysfunction of pancreatic beta cells and in the development of vascular diabetic complications. Accordingly, antioxidant therapies have been gaining recognition as strategies to reduce their detrimental effects. Dietary flavanols are natural antioxidant compounds abundant in fruits and vegetables. Most of them reach the colon where they are biotransformed by the colonic microbiota into low-molecular-weight metabolites before absorption. Therefore, the aim of this work was to establish the potential of the microbial-derived flavanol metabolites 3,4-dihydroxyphenylacetic acid (DHPA), 2,3-dihydroxybenzoic acid (DHB) and 3-hydroxyphenylpropionic acid (HPP) to prevent oxidative stress in pancreatic and endothelial cells.
DescriptionTrabajo presentado a la Reunión Anual CIBERDEM, celebrada en Madrid del 17 al 19 de mayo de 2017.
Appears in Collections:(ICTAN) Comunicaciones congresos
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