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The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces

AuthorsSantamaría, Ramón I. ; Sevillano, Laura ; Martín, Jesús; Genilloud, Olga; González, Ignacio; Díaz, Margarita
Positive regulator
Antibiotic production
Xenobiotic response element
Issue Date16-Nov-2018
PublisherFrontiers Media
CitationFrontiers in Microbiology 9: 2791 (2018)
AbstractThe xenobiotic response element (XRE) transcription factors belong to a regulator family frequently found in Streptomyces that are often followed by small proteins with a DUF397 domain. In fact, the pair XRE-DUF397 has been proposed to comprise toxin–antitoxin (TA) type II systems. In this work, we demonstrate that one of these putative TA-systems, encoded by the genes SCO4441 and SCO4442 of Streptomyces coelicolor, and denominated Scr1/Scr2 (which stands for S. coelicolor regulator), does not behave as a toxin–antitoxin system under the conditions used as was originally expected. Instead the pair Scr1/Scr2 acts as a strong positive regulator of endogenous antibiotic production in S. coelicolor. The analysis of the 19 Streptomyces strains tested determined that overexpression of the pair Scr1/Scr2 drastically induces the production of antibiotics not only in S. coelicolor, but also in Streptomyces lividans, Streptomyces peucetius, Streptomyces steffisburgensis and Streptomyces sp. CA-240608. Our work also shows that Scr1 needs Scr2 to exert positive regulation on antibiotic production.
Publisher version (URL)https://doi.org/10.3389/fmicb.2018.02791
Appears in Collections:(IBFG) Artículos
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