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Inflammatory biomarkers and obesity in youth with and without down syndrome
|Authors:||Gutiérrez-Hervás, Ana; Gómez Martínez, Sonia ; Veses, Ana M. ; Izquierdo-Gómez, Rocío; Veiga, Óscar; Delgado Alfonso, Alvaro; Castro-Piñero, José; Santiago, Catalina; Gómez-Gallego, Félix; Marcos, Ascensión|
Children and adolescents
|Citation:||International Symposium on Immunonutrition (2017)|
|Abstract:||[Background and Objective]: Inflammation has been related to obesity and its associated pathologies, such as cardiovascular diseases and metabolism alterations. Adipose tissue excess leads to elevated inflammatory biomarkers, although there is still a lack of knowledge on children and adolescents, particularly in a very special group such as subjects with Down syndrome (DS). This study was aimed to evaluate possible associations between inflammatory biomarkers and obesity in a sample of children and adolescents with DS and without DS (controls).|
[Methods]: A total of 502 children and adolescents (101 with DS) aged 10–20 years-old, were recruited in this UP&DOWN substudy. Insulin, leptin, TNF-α, adiponectin, galactain3, visfatin and cortisol were selected as inflammatory biomarkers. Height and weight were measured and Body Mass Index (BMI) was calculated. Pearson correlations were executed.
[Results]: 65.3% and 31.9% of the volunteers had values below the level of detection in the visfatin (0.156 ng/ml) and insulin (1.00 pg/ml) test respectively. BMI was higher in DS than in controls (p < 0.001). Galactin-3 and adiponectin levels were lower in DS than in controls (p < 0.001). BMI was positively correlated with leptin and insulin and negatively with adiponectin in both groups. On the other hand, BMI positively correlated with TNF-α and cortisol in the control group and negatively with visfatin in the DS group (all p < 0.05).
[Conclusions]: These results point out that children and adolescents with SD have a peculiar inflammatory behaviour. An exhaustive study of the relationships between body composition and inflammatory biomarkers should be further evaluated in this group of population.
|Description:||Resumen del trabajo presentado al International Symposium on Immunonutrition (10th Anniversary), celebrado en Madrid (España) del 17 al 19 de julio de 2017.|
|Appears in Collections:||(ICTAN) Comunicaciones congresos|