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Inflammatory biomarkers and obesity in youth with and without down syndrome

AuthorsGutiérrez-Hervás, Ana; Gómez Martínez, Sonia ; Veses, Ana M. ; Izquierdo-Gómez, Rocío; Veiga, Óscar; Delgado Alfonso, Alvaro; Castro-Piñero, José; Santiago, Catalina; Gómez-Gallego, Félix; Marcos, Ascensión
KeywordsInflammatory biomarkers
Down syndrome
Children and adolescents
Issue Date2017
CitationInternational Symposium on Immunonutrition (2017)
Abstract[Background and Objective]: Inflammation has been related to obesity and its associated pathologies, such as cardiovascular diseases and metabolism alterations. Adipose tissue excess leads to elevated inflammatory biomarkers, although there is still a lack of knowledge on children and adolescents, particularly in a very special group such as subjects with Down syndrome (DS). This study was aimed to evaluate possible associations between inflammatory biomarkers and obesity in a sample of children and adolescents with DS and without DS (controls).
[Methods]: A total of 502 children and adolescents (101 with DS) aged 10–20 years-old, were recruited in this UP&DOWN substudy. Insulin, leptin, TNF-α, adiponectin, galactain3, visfatin and cortisol were selected as inflammatory biomarkers. Height and weight were measured and Body Mass Index (BMI) was calculated. Pearson correlations were executed.
[Results]: 65.3% and 31.9% of the volunteers had values below the level of detection in the visfatin (0.156 ng/ml) and insulin (1.00 pg/ml) test respectively. BMI was higher in DS than in controls (p < 0.001). Galactin-3 and adiponectin levels were lower in DS than in controls (p < 0.001). BMI was positively correlated with leptin and insulin and negatively with adiponectin in both groups. On the other hand, BMI positively correlated with TNF-α and cortisol in the control group and negatively with visfatin in the DS group (all p < 0.05).
[Conclusions]: These results point out that children and adolescents with SD have a peculiar inflammatory behaviour. An exhaustive study of the relationships between body composition and inflammatory biomarkers should be further evaluated in this group of population.
DescriptionResumen del trabajo presentado al International Symposium on Immunonutrition (10th Anniversary), celebrado en Madrid (España) del 17 al 19 de julio de 2017.
Appears in Collections:(ICTAN) Comunicaciones congresos
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