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dc.contributor.authorCabezas-Cruz, Alejandro-
dc.contributor.authorAlberdi, Pilar-
dc.contributor.authorValdés, James J.-
dc.contributor.authorVillar, Margarita-
dc.contributor.authorFuente, José de la-
dc.date.accessioned2018-11-07T10:02:45Z-
dc.date.available2018-11-07T10:02:45Z-
dc.date.issued2017-
dc.identifierdoi: 10.2741/4574-
dc.identifierissn: 1093-9946-
dc.identifiere-issn: 1093-4715-
dc.identifier.citationFrontiers in Bioscience 22: 1830-1844 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/171972-
dc.description.abstractThe obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, Ixodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that were recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks.-
dc.description.sponsorshipThis research was supported by the Ministerio de Economia, Industria y Competitividad (Spain) grant BFU2016–79892-P and the European Union (EU) Seventh Framework Programme (FP7) ANTIGONE project number 278976. MV was supported by the Research Plan of the UCLM.-
dc.publisherFrontiers in Bioscience Publications-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/278976-
dc.relationMINECO/ICTI2013-2016/BFU2016–79892-P-
dc.rightsclosedAccess-
dc.subjectIxodes scapularis-
dc.subjectAnaplasma phagocytophilum-
dc.subjectTranscriptomics-
dc.subjectProteomics-
dc.subjectCytoskeleton-
dc.titleRemodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum-
dc.typeartículo-
dc.date.updated2018-11-07T10:02:45Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)-
dc.contributor.funderUniversidad de Castilla La Mancha-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007480es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010198es_ES
dc.identifier.pmid28410148-
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