English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/171971
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Infection-derived lipids elicit an immune deficiency circuit in arthropods

AuthorsShaw, Dana K.; Wang, Xiaowei; Brown, Lindsey J.; Oliva Chávez, Adela S.; Reif, Kathryn E.; Smith, Alexis A.; Scott, Alison J.; McClure, Erin E.; Boradia, Vishat M.; Hammond, Holly L.; Sundberg, Eric J.; Snyder, Greg A.; Liu, Lei; Deponte, Kathleen; Villar, Margarita ; Ueti, Massaro; Fuente, José de la ; Ernst, Robert K.; Pal, Utpal; Fikrig, Erol; Pedra, Joao H. F.
Issue Date2017
PublisherNature Publishing Group
CitationNature Communications 8: 14401 (2017)
AbstractThe insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks.
Publisher version (URL)https://doi.org/10.1038/ncomms14401
Identifiersdoi: 10.1038/ncomms14401
e-issn: 2041-1723
Appears in Collections:(IREC) Artículos
Files in This Item:
File Description SizeFormat 
infectarthro.pdf2,92 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.