English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/171795
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations

AuthorsMoreno, María Alejandra; Gómez-Mascaraque, Laura G. CSIC ORCID; Arias, Myriam; Zampini, Iris Catiana; Sayago, Jorge Esteban; Pino Ramos, Leidy Liudis; Schmeda-Hirschmann, Guillermo; López-Rubio, Amparo CSIC ORCID; Isla, María Inés
Argentinean dry plant extracts
Vaginal tablets
Issue Date22-Aug-2018
CitationCarbohydrate Polymers 201: 425-437 (2018)
AbstractThe design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment.
Publisher version (URL)https://doi.org/10.1016/j.carbpol.2018.08.084
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Carb Pol_2018-Moreno.pdfArtículo principal2,41 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.