English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/171689
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Preliminary study about the relationship between non-extractable polyphenols from diet, gut microbiota and oxidative stress

AuthorsGutiérrez-Díaz, Isabel; Fernández-Navarro, Tania; Pérez-Jiménez, Jara ; Salazar, Nuria ; González de los Reyes-Gavilán, Clara ; Gueimonde Fernández, Miguel ; González, Sonia
Issue Date2018
Citation9th Workshop Probiotics and Prebiotics (2018)
Abstract[Introduction]: Epidemiological studies have suggested an association between polyphenols intake and oxidative stress-related diseases. Information about the intake of polyphenols in human populations has been limited to the data available in nutrient databases, which do not include the food content of non-extractable polyphenols (NEPP). Recently, the information relative to these compounds in Spanish fruits and vegetables has been published. Thus, since they are associated with the insoluble food matrix and may reach completely intact the colon, these compounds are of special interest in the study of diet-microbiota interactions. [Objectives]: To analyse the intake of the total NEPP and their subclasses in a healthy adult population and to explore the relationship with the gut microbiota and oxidative stress biomarkers. [Methods]: This study involved 103 healthy adults. Dietary intake was assessed by an annual food frequency questionnaire. NEPP content data were extracted from Pérez-Jimémez et al. and dietary fiber content data from Marlet et al. Serum malondialdehyde (MDA) levels were determined and the major phylogenetic microbial types present in the gut quantified by qPCR. [Results]: NEPP represent a 73.64% of the total phenolic intake. From them, hydrolysable polyphenols, and non-extractable flavonols, hydroxybenzoic and hydroxycinnamic acids, were negatively associated with MDA. Non-extractable hydroxybenzoic acid was found to be an independent contributor to Bacteroides-Prevotella-Porphyromonas group levels (R2=0.053, β=0.230), whereas Clostridium cluster XVIa variation was explained by the intake of non-extractable flavonols and Klason lignin (R2=0.150, β=-0.318 and 0.297, respectively). Moreover, the levels of Lactobacillus group were associated with non-extractable flavonols intake (R2=0.095, β=-0.308). [Conclusions]: NEPP are associated with some of the major intestinal microbial groups and oxidative stress. Our data could be of great interest for future studies in order to elucidate the complex relation among diet-microbiota-health.
DescriptionResumen del trabajo presentado al 9th Workshop Probiotics and Prebiotics of the Spanish Society of Probiotics and Prebiotics (SEPyP), celebrado en Zaragoza del 15 al 16 de febrero de 2018.
URIhttp://hdl.handle.net/10261/171689
Appears in Collections:(ICTAN) Comunicaciones congresos
(IPLA) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.