English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/171572
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorDzidic, Majdaes_ES
dc.contributor.authorAbrahamsson,Thomases_ES
dc.contributor.authorArtacho, Alejandroes_ES
dc.contributor.authorCollado, María Carmenes_ES
dc.contributor.authorMira, Alexes_ES
dc.contributor.authorJenmalm, Mariaes_ES
dc.date.accessioned2018-10-25T10:14:41Z-
dc.date.available2018-10-25T10:14:41Z-
dc.date.issued2018-03-30-
dc.identifier.citationAllergy 73 (10): 2000-2011 (2018)es_ES
dc.identifier.issn0105-4538-
dc.identifier.urihttp://hdl.handle.net/10261/171572-
dc.description.abstractBackground: Allergic diseases have become a major public health problem in affluent societies. Microbial colonization early in life seems to be critical for instructing regulation on immune system maturation and allergy development in children. Even though the oral cavity is the first site of encounter between a majority of foreign antigens and the immune system, the influence of oral bacteria on allergy development has not yet been reported. Objective: We sought to determine the bacterial composition in longitudinally collected saliva samples during childhood in relation to allergy development. Methods: Illumina sequencing of the 16S rDNA gene was used to characterize the oral bacterial composition in saliva samples collected at 3, 6, 12, 24 months, and 7 years of age from children developing allergic symptoms and sensitization (n = 47) and children staying healthy (n = 33) up to 7 years of age. Results: Children developing allergic disease, particularly asthma, had lower diversity of salivary bacteria together with highly divergent bacterial composition at 7 years of age, showing a clearly altered oral microbiota in these individuals, likely as a consequence of an impaired immune system during infancy. Moreover, the relative amounts of several bacterial species, including increased abundance of Gemella haemolysans in children developing allergies and Lactobacillus gasseri and L. crispatus in healthy children, were distinctive during early infancy, likely influencing early immune maturation. Conclusion: Early changes in oral microbial composition seem to influence immune maturation and allergy development. Future experiments should test the probiotic potential of L. gasseri and L. crispatus isolates.es_ES
dc.description.sponsorshipFunding information: Alex Mira: Spanish Ministry of Economy and Competitiveness (grant no. BIO2015‐68711‐R). Maria C. Jenmalm: The Swedish Research Council (2016‐01698); the Swedish Heart and Lung Foundation (20140321); the Medical Research Council of Southeast Sweden (FORSS‐573471); and the Cancer and Allergy Foundation. Maria Carmen Collado: European Research Council (ERC‐starting grant 639226).es_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationMINECO/ICTI2013-2016/BIO2015‐68711‐Res_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/639226-
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectAllergy developmentes_ES
dc.subjectGemella haemolysanses_ES
dc.subjectinfancyes_ES
dc.subjectLactobacilluses_ES
dc.subjectOral microbiotaes_ES
dc.titleOral microbiota maturation during the first 7 years of life in relation to allergy developmentes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1111/all.13449-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1111/all.13449es_ES
dc.embargo.terms2019-03-30es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderSwedish Research Counciles_ES
dc.contributor.funderSwedish Heart-Lung Foundationes_ES
dc.contributor.funderEuropean Research Counciles_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Allergy_Dzidic_2018.pdfArtículo principal368,63 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.