English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/171478
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorMoreno-Fernández, Silvia-
dc.contributor.authorGarcés Rimón, M.-
dc.contributor.authorVera, Gema-
dc.contributor.authorAstier, Julien-
dc.contributor.authorLandrier, Jean François-
dc.contributor.authorMiguel, Marta-
dc.date.accessioned2018-10-24T08:17:27Z-
dc.date.available2018-10-24T08:17:27Z-
dc.date.issued2018-10-14-
dc.identifier.citationNutrients 10(10): 1502 (2018)-
dc.identifier.urihttp://hdl.handle.net/10261/171478-
dc.description.abstractMetabolic syndrome (MetS) is defined as a constellation of many metabolic disorders such as hypertension, impaired glucose tolerance, dyslipidemia and obesity, being this last disorder a key factor in the etiology of the syndrome. The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast. The main objective of the present study was to evaluate the MetS-associated alterations developed in a new glucose diet-induced-obesity (DIO) rodent model. These alterations were also compared to those alterations developed in a fructose-DIO rodent model. Wistar rats were divided into four groups: Control (C), High-fat (HF), High-fat/high-fructose (HFF) and High-fat/high-glucose (HFG). The animals were fed ad libitum for 20 weeks. At the end of the study, HFG animals showed lower expression of energy expenditure genes when compared to the other DIO groups. Oxidative stress biomarkers such as MDA and mitochondrial RT-qPCR analyses showed an increase of oxidative damage together with mitochondrial dysfunction in HFG group. This group also showed increased insulin and glucose plasma levels, though HFF animals showed the greatest increase on these parameters. All DIO groups showed increased plasma levels of triglycerides. Altogether, our results indicated a better impact of glucose than fructose, when combined with a high-fat diet, to induce most of the alterations associated with MetS in rats. In addition, our research facilitates a new animal model to evaluate future treatments for MetS.-
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) (under the projects AGL2012-32387, AGL2017-89213 and CSIC-INTRAMURAL 201570I028 and under the grant numbers BES-2013-065684 and EEBB-I-16-11349).-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMINECO/ICTI2013-2016/AGL2017-89213-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectMetabolic syndrome-
dc.subjectObesity-
dc.subjectDiet induced obesity-
dc.subjectRat model-
dc.subjectHigh glucose-
dc.subjectHigh fructose-
dc.titleHigh Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model-
dc.typeArtículo-
dc.identifier.doi10.3390/nu10101502-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/nu10101502-
dc.identifier.e-issn2072-6643-
dc.date.updated2018-10-24T08:17:27Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
nutrients-10-01502.pdf2,24 MBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.