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dc.contributor.authorRuiz, Alicia-
dc.contributor.authorCerdó, Tomás-
dc.contributor.authorJáuregui, Ruy-
dc.contributor.authorPieper, Dietmar H.-
dc.contributor.authorMarcos, Ascensión-
dc.contributor.authorClemente, Alfonso-
dc.contributor.authorGarcía, Federico-
dc.contributor.authorMargolles Barros, Abelardo-
dc.contributor.authorFerrer, Manuel-
dc.contributor.authorCampoy, Cristina-
dc.contributor.authorSuárez, Antonio-
dc.identifierdoi: 10.1111/1462-2920.13713-
dc.identifiere-issn: 1462-2920-
dc.identifierissn: 1462-2912-
dc.identifier.citationEnvironmental Microbiology 19(4): 1536-1551 (2017)-
dc.description.abstractRecent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium. Only long-term calorie restriction induced clear changes in the microbiota of obese adolescents. Long-term calorie restriction induced significant shifts in total and βGAL gut microbiota, reducing the Firmicutes:Bacteroidetes ratio and enhancing the growth of beneficial microorganisms such as Bacteroides, Roseburia, Faecalibacterium and Clostridium XIVa. Moreover, the structure and composition of βGAL community in obese after long-term calorie restriction was highly similar to that of lean adolescents. However, despite this high compositional similarity, microbial metabolic performance was different, split in two metabolic states at a body mass index value of 25. Our study shows that calorie restriction is a strong environmental force reshaping gut microbiota though its metabolic performance is linked to host's adiposity, suggesting that functional redundancy and metabolic plasticity are fundamental properties of gut microbial ecosystem.-
dc.description.sponsorshipThis work was funded by Carlos III Institute of Health, (Grants PI 051579, PI021513) and the Economy, Industry and Competitiveness Ministry (Grant AGL-11697/ALI). AR and TC received PhD FPU and FPI fellowships, respectively, from the Spanish Ministery of Economy and Competitivity. TC participated in the PhD Program in Biomedicine of the University.-
dc.publisherSociety for Applied Microbiology-
dc.publisherJohn Wiley & Sons-
dc.titleOne-year calorie restriction impacts gut microbial composition but not its metabolic performance in obese adolescents-
dc.description.versionPeer Reviewed-
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderUniversidad Carlos III de Madrid-
dc.contributor.funderInstituto de Salud Carlos III-
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